Mastodon provides several tools for managing your timeline.
You can add notes to any profile. Why did you follow them? Are they a repeat offender? Remind yourself.
You can disable boosts on a per-user basis. Maybe you want to see a user's posts, but not everything that interests them.
You can temporarily mute an account while they get something out of their system.
You filter out posts with specific words, hashtags or phrases.
And when all else fails: block, unfollow, or mute indefinitely.
Reminder: if, like me, you just arrived here from twitter, then nobody knows who you are. And if you don't put something in your profile, it makes it really hard to reconnect with you (even if it's just "I'm on twitter as @cstross)!
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